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The paper discusses general problems in using PEG for conjugation to high or low molecular weight molecules. Poly (ethylene glycol) (PEG) is a highly investigated polymer for the covalent modification of biological macromolecules and surfaces for many pharmaceutical and biotechnical applications. PEGylation is the process of covalent attachment of polyethylene glycol (PEG) polymer chains to ano...
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IN HISTORICAL REFERENCES TO WHAT TODAY WOULD BE CONSIDERED MAJOR DEPRESSION, MOOD DISORDERS HAVE LONG BEEN ASSOCIATED WITH CHANGES IN SLEEP PATTERNS. Using the term melancholia, Hippocrates (460-377 BC) already described many features, including “loss of sleep,” by which we define major depressive disorder (MDD) today. Subjective sleep complaints are frequently present in depressed patients,1,2...
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ژورنال
عنوان ژورنال: EMBnet.journal
سال: 2018
ISSN: 2226-6089
DOI: 10.14806/ej.24.0.915